phenobarbital will minimize the level or result of eltrombopag by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Observe.Keep track of Closely (one)phenobarbital will minimize the level or impact of tofacitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Lack of, or lowered reaction to tofacitinib may pe